Paxidep CR tablets uses and side effects
Paxidep CR is an Indian brand of SSRI (Selective serotonin reuptake inhibitor) antidepressant. Its generic name is paroxetine. It is prescribed for depression, panic disorder and other anxiety disorders. It is especially prescribed for breastfeeding mothers due to low concentration of the medication in breast milk. CR is shortened name for controlled release. It means once the medication is ingested, tablet will release the active drug into the blood slowly. Therefore it will cause less side effects.
However, this medication is having side effects common to SSRI class medications such as nausea, heartburn and headache. In addition, compared to other SSRI medications, it can cause more fetal malformations. Therefore, this medication should be discontinued in pregnancy.
Uses of Paxidep CR
This medication is prescribed for major depression, panic disorder and other anxiety disorders. Clinical depression is characterized by persistent low mood, low energy, and lack of enjoyment of previously enjoyable activities lasting for more than two weeks. In addition, depression can cause suicidal ideation.
Panic and other anxiety disorders are characterized by inappropriate anxiety (“a feeling of worry, nervousness, or unease, typically about an imminent event or something with an uncertain outcome.”) that can cause severe functional impairment in the affected individual.
In addition, Paxidep CR is effective in obsessive compulsive disorders (OCD). Obsessive compulsive disorder is characterized by inappropriately repetitive behavior which is senseless and resisted by the individual. E.g Repetitive hand washing to wash away germs.
This medication is preferred antidepressant in breastfeeding due to minimal drug concentration in breast milk. However, it should not be used by pregnant women. Therefore, breast feeding women should take adequate contraception during treatment.
What are the common side effects of Paxidep CR?
Loss of appetite
Increased blood cholesterol
What are the rare side effects of this medication?
Documented harm to the baby when the mother takes this medication.
Initial increase of anxiety when prescribed for anxiety disorders. Due to this risk many doctors prescribe low doses at the initial period of illness. But this effect usually wanes after that.
Hives and allergic reaction
Risk of mania (Opposite of depression with excessive energy, elevated self-esteem that can cause severe social malfunction)
Reduced salt levels in blood
Increased risk of bleeding
How Paxidep CR is prescribed?
This medication is available as tablets. Usual dose range is between 12.5 to 37.5mg per day. Elderly patients will get maximum daily dose of 25mg. Usually the medication is prescribed in morning due to the disturbance of sleep associated with this medication.
This medication should be taken with meals to minimize side effects. It should be taken with a full glass of water and the tablet should not be crushed/broken.
What the doctor should know before prescribing this medication
Bipolar affective disorder
Pregnancy status (should not be given in first trimester of pregnancy)
Long standing gastritis
Paxidep CR is a controlled release SSRI class medication prescribed for depression and anxiety disorders. Main side effects are nausea, heart burn and sexual dysfunction. This medication should not be prescribed for pregnant women who are in their first trimester.
Please consult your physician
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